![]() However, the molecular pathways involved in the manipulation of host cell death, and the consequence of this on the outcome of the infection, remain highly controversial 7, 8, 9. ![]() Successful implementation of such drugs requires fundamental understanding of cell-death mechanisms exploited by Mtb. One possible approach is to inhibit cell death induced by phagocytosed Mtb which can prevent mycobacterial spread, tissue damage, and hyperinflammation 3. Adjunctive host-directed therapy (HDT) might improve and accelerate treatment by modifying host pathways targeted by the intracellular pathogen Mtb 2, 3, 4, 5, 6. Clinical management of TB consists of combinations of antibiotics for several months, a concept which becomes increasingly complicated in times of rising numbers of multi-drug resistant Mtb-isolates 1. M ycobacterium tuberculosis ( Mtb), the causative agent of tuberculosis (TB), is the major killer among infectious agents which led to 1.7 million deaths in 2016 (ref. ![]()
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